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If you are being treated with any of the following medications, you should not use milk thistle without first talking to your health care provider.
Antipsychotics -- includes butyrophenones (such as haloperidol) and phenothiazines (such as chlorpromazine, fluphenazine, and promethazine)
Phenytoin(Dilantin) -- a medication used for seizures
Halothane -- a medication used during general anesthesia
Birth control pills or hormone replacement therapy
Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes:
Allergy drugs -- such as fexofenadine (Allegra)
Drugs for high cholesterol -- including statins such as lovastatin (Mevacor, Altocor)
Antianxiety drugs -- including alprazolam (Xanax), diazepam (Valium), and lorazepam (Ativan)
Antiplatelet and anticoagulant drugs (blood thinners) -- including clopidogrel (Plavix) and warfarin (Coumadin)
Some cancer drugs
Drugs broken down by the liver -- because milk thistle works on the liver, it may affect drugs broken down by the liver, of which there are many. Speak with your health care provider.