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I'd be very interested to hear folks opinions on the idea of a genetic predisposition towards addictive patterns of behaviour.I don't know if it's genetic, but I seem to be fairly non-addictive. I've had periods in which I've used marijuana, vicodin, oxycontin, pretty regularly for extended periods of time... then just quit when the supply dried up, and simply didn't look back. Even though I drink alcohol and caffeine pretty much daily, I've quit both cold-turkey for like backpacking trips, and wasn't bothered. And then there's the stuff like E or coke or amphetamines, which I usually did just once in a while before I quit that crap.
My policy is to take a quarter-dose of anything I haven't tried before, just to get the feel of the mental effects at a low level so I know how to handle them at higher doses.