Vanilla is a product of Lussumo:
Documentation and Support.
Since time is subjective, what would the travelers find when they came home from their ten year trip to God knows where?
Are people willing to invest - both personally and financially - in these types of very long term endeavors anymore? I think that there are people out there that would do it, but probably not individuals with qualities that governments or corporations would want to send.
Also, could you imagine showing a corporate finance department a project with a return on investment of about 500 years. Not many investors could stomach that.
Any successful effort at establishing an infrastructure for space exploration and colonization is going to be a one way trip for most people at least in the first few centuries.
Here is an idea: Send battle-hardened, strong-minded soldiers and marines on the long trips into space. We are conditioned to live with the bare minimal (of) life’s necessities and are trained to be prepared for … the worst conditions that any environment could throw at us.
Hell, me and my men will go, set up a colony somewhere and await colonists to arrive.