Something Wonderful - provocative humour with apologetic explanations by the same artist
Spazzmoid - whatever's on Bob Byrne's mind, sometimes autobiographical, sometimes bad taste humour
And I think after that I'm entitled to plug my own, The Cattle Raid of Cooley a serial adaptation of the Iron Age Irish epic. And you'll probably want to check out the various "webcomics week" threads we've had here for others.
Axe Cop Cyanide and Happiness Bad Machinery (probably need to go through the archives first to enjoy this one) I also read Occasional Comics and Hark! A Vagrant, but they've been linked already.
Not counting FA, the only ones I read religiously are xkcd and Penny Arcade, though I stumble across DInosaur Comics and Hark! once in a while.
I've pimped my own comic a lot here lately, so I'll make a point of not mentioning it again just now. Of course, if one were to find their way into my User Details...
Gotta love Hark! a Vagrant. I adore Kate Beaton and her sence of homour+expressive drawing style. Secretly this was all a ploy to get lots of new links. My computers hard drive died two weeks ago and I lost all my bookmarks :/
I wanna say Gunshow's been around since 2008. The Anime Club made their first appearance maybe in early 09? I think the big strips are pretty new, since Green is still working on them and they're done in his most recent style.
I'm really enjoying all of writer Kevin Church's Agreeable Comics. He's got 3 different serials running at the moment, and the two inactive strips (Lydia and Waimea) are also well worth checking out. They're also gorgeous, courtesy of artists Benjamin Birdie, Ming Doyle, and TJ Kirsch. (And Lydia and Waimea are similarly rendered by Max Riffner and Mike Dake, respectively)
Freakangels Phil & Kaja Foglio's Girl Genius Ursula Vernon's Digger (Incredible art, a very Terry Pratchett sense of humor/drama, and a wombat.) Wendy Pini's Masque of the Red Death (I would ALMOST tradewait this one - I don't like the Flash semi-motion-comic format, and the art is even more stunning in print - but too good to ignore while waiting for the trades.) Erin Lindsey's Venus Envy (Sporadic and hasn't updated since sometime in March. Catch up on the archives and hope.)
Rice Boy (this one's aleady finished, but by the guy who's now doing Order of Tales) Hanna is Not a Boy's Name < the art in this is so pretty I kind of can't stand it.